Parkinson’s disease

Parkinson’s Disease

(As defined by the Parkinson’s disease Foundation)

Parkinson’s disease (PD) is a chronic and progressive movement disorder, meaning that symptoms continue and worsen over time. Nearly one million people in the US are living with Parkinson’s disease. The cause is unknown, and although there is presently no cure, there are treatment options such as medication and surgery to manage its symptoms.

Parkinson’s involves the malfunction and death of vital nerve cells in the brain, called neurons. Parkinson’s primarily affects neurons in an area of the brain called the substantia nigra. Some of these dying neurons produce dopamine, a chemical that sends messages to the part of the brain that controls movement and coordination. As PD progresses, the amount of dopamine produced in the brain decreases, leaving a person unable to control movement normally.

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The specific group of symptoms that an individual experiences varies from person to person. Primary motor signs of Parkinson’s disease include the following.

tremor of the hands, arms, legs, jaw and face

bradykinesia or slowness of movement

rigidity or stiffness of the limbs and trunk

postural instability or impaired balance and coordination

Scientists are also exploring the idea that loss of cells in other areas of the brain and body contribute to Parkinson’s. For example, researchers have discovered that the hallmark sign of Parkinson’s disease — clumps of a protein alpha-synuclein, which are also called Lewy Bodies — are found not only in the mid-brain but also in the brain stem and the olfactory bulb.

These areas of the brain correlate to nonmotor functions such as sense of smell and sleep regulation. The presence of Lewy bodies in these areas could explain the nonmotor symptoms experienced by some people with PD before any motor sign of the disease appears. The intestines also have dopamine cells that degenerate in Parkinson’s, and this may be important in the gastrointestinal symptoms that are part of the disease.

According to a study conducted at Charles’s University in Prague by the department of Neurology, researchers concluded:

“An anonymous questionnaire sent to all patients attending the Prague Movement Disorder Centre revealed that 25% of the 339 respondents had taken cannabis and 45.9% of these described some form of benefit…

The late onset of cannabis action is noteworthy. Because most patients reported that improvement occurred approximately two months after the first use of cannabis, it is very unlikely that it could be attributed to a placebo reaction.

“Because Parkinson’s is essentially a condition of deficient dopamine in the brain, the most direct solution is to supplement the dopamine. The only problem is that dopamine itself is not able to cross the blood-brain barrier. However, it’s precursor, levodopa can enter the brain easily and be converted to dopamine. Cannabinoids can relive symptoms, such as dystonia and dyskinesia, which are prevalent in some patients suffering from Parkinson’s disease.” THC